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Contents

  1. 6.1 Gamma Camera Components (Collimator, Crystal, PMT)
  2. 6.1.1 General Structure and Principle of Operation
  3. 6.1.2 Collimator
  4. 6.1.3 NaI(Tl) Scintillation Crystal
  5. 6.1.4 Light Guide
  6. 6.1.5 Photomultiplier Tubes (PMT)
  7. 6.1.6 Position Circuitry (Anger Logic)
  8. 6.1.7 Pulse Height Analyser (PHA) and Energy Window
  9. 6.2 Collimator Types and Selection
  10. 6.2.1 Parallel-Hole Collimators
  11. 6.2.2 Pinhole Collimator
  12. 6.2.3 Converging Collimator
  13. 6.2.4 Diverging Collimator
  14. 6.2.5 Collimator Types – Comparative Summary
  15. 6.3 Energy Window and Pulse Height Analyser
  16. 6.3.1 Role of the PHA in the Gamma Camera
  17. 6.3.2 Single and Multiple Energy Windows
  18. 6.3.3 Scatter Correction Windows
  19. 6.4 SPECT Principle and Acquisition
  20. 6.4.1 Basic Principle of SPECT
  21. 6.4.2 SPECT Acquisition Parameters
  22. 6.4.3 SPECT Reconstruction
  23. 6.4.4 SPECT Image Orientation
  24. 6.5 SPECT/CT Hybrid Imaging
  25. 6.5.1 Basic Principle of SPECT/CT
  26. 6.5.2 The CT Component of SPECT/CT
  27. 6.5.3 SPECT/CT Registration and Artefacts
  28. 6.5.4 Clinical Applications of SPECT/CT
  29. 6.5.5 Quantitative SPECT/CT and Patient-Specific Dosimetry
  30. 6.6 Gamma Camera Performance Parameters
  31. 6.6.1 Spatial Resolution
  32. 6.6.2 Sensitivity
  33. 6.6.3 Uniformity
  34. 6.6.4 Energy Resolution
  35. 6.6.5 Count Rate Performance
  36. 6.6.6 Spatial Linearity
  37. 6.6.7 Performance Parameters Summary Table
  38. Key Points for the Board
  39. Current guidelines on this chapter's topics
← Back‹ Chapter 5Chapter 7 ›

Chapter 06Basic sciencesLast reviewed: 14 Nov 2026 · What's new

Gamma Camera and SPECT/CT

This chapter's English text is a draft translation (prepared with Claude and checked against a terminology glossary and automatic checks); specialist review is in progress. Please report errors with the feedback button.

Solve questions (26) →
Contents
  1. 6.1 Gamma Camera Components (Collimator, Crystal, PMT)
  2. 6.1.1 General Structure and Principle of Operation
  3. 6.1.2 Collimator
  4. 6.1.3 NaI(Tl) Scintillation Crystal
  5. 6.1.4 Light Guide
  6. 6.1.5 Photomultiplier Tubes (PMT)
  7. 6.1.6 Position Circuitry (Anger Logic)
  8. 6.1.7 Pulse Height Analyser (PHA) and Energy Window
  9. 6.2 Collimator Types and Selection
  10. 6.2.1 Parallel-Hole Collimators
  11. 6.2.2 Pinhole Collimator
  12. 6.2.3 Converging Collimator
  13. 6.2.4 Diverging Collimator
  14. 6.2.5 Collimator Types – Comparative Summary
  15. 6.3 Energy Window and Pulse Height Analyser
  16. 6.3.1 Role of the PHA in the Gamma Camera
  17. 6.3.2 Single and Multiple Energy Windows
  18. 6.3.3 Scatter Correction Windows
  19. 6.4 SPECT Principle and Acquisition
  20. 6.4.1 Basic Principle of SPECT
  21. 6.4.2 SPECT Acquisition Parameters
  22. 6.4.3 SPECT Reconstruction
  23. 6.4.4 SPECT Image Orientation
  24. 6.5 SPECT/CT Hybrid Imaging
  25. 6.5.1 Basic Principle of SPECT/CT
  26. 6.5.2 The CT Component of SPECT/CT
  27. 6.5.3 SPECT/CT Registration and Artefacts
  28. 6.5.4 Clinical Applications of SPECT/CT
  29. 6.5.5 Quantitative SPECT/CT and Patient-Specific Dosimetry
  30. 6.6 Gamma Camera Performance Parameters
  31. 6.6.1 Spatial Resolution
  32. 6.6.2 Sensitivity
  33. 6.6.3 Uniformity
  34. 6.6.4 Energy Resolution
  35. 6.6.5 Count Rate Performance
  36. 6.6.6 Spatial Linearity
  37. 6.6.7 Performance Parameters Summary Table
  38. Key Points for the Board
  39. Current guidelines on this chapter's topics
Learning objectives and modules3 modules · about 2 h 30 min

Learning objectives

After this chapter you will be able to:

  • Explain the components of the gamma camera and how Anger logic determines position and energy.
  • Compare collimator types; select a collimator by energy and study type and explain the resolution–sensitivity trade-off.
  • Explain the role of the energy window and pulse height analysis in reducing scatter.
  • Select SPECT acquisition parameters (orbit, arc, number of projections, matrix) for the study type.
  • Explain the role of CT in attenuation correction and localisation in SPECT/CT and the artefacts it may cause.
  • Define the performance parameters of the gamma camera (resolution, uniformity, energy resolution, dead time).

Modules

The chapter is divided into study modules without changing the order of the text: read, watch the animations, then answer the questions linked to those headings.

  1. Module 16.1–6.2 Gamma Camera Components (Collimator, Crystal, PMT) · Collimator Types and Selection1 h · 3 animations · 22 questionsAnswer the questions →
  2. Module 26.3–6.5 Energy Window and Pulse Height Analyser · SPECT Principle and Acquisition · SPECT/CT Hybrid Imaging55 min · 2 animations · 21 questionsAnswer the questions →
  3. Module 36.6 Gamma Camera Performance Parameters · Key Points for the Board35 min · 1 animation · 10 questionsAnswer the questions →

Times are estimates: 130 words per minute, 3 min per animation, 1.5 min per question.

Tip cards (45) →

MOST FREQUENTLY ASKED IN THIS CHAPTER

✓
First commercial SPECT/CT: GE, 1999 → low-dose single-slice CT (~3.5 mm)
✓
The effective dose contribution of CT is ~1-10 mSv; low-mAs CT is often sufficient for localisation/AC
✓
HU = [(µtissue − µwater)/µwater] × 1000; HU → µ conversion is bilinear (with a phantom)
✓
Misregistration: Respiration (SPECT averaged vs CT instantaneous), table sag, axial centre offset
✓
Truncation, beam hardening, metal, iodinated contrast → AC artefacts
✓
Dosimetry: VOIs are drawn on CT → transferred to SPECT; successive time points are aligned by CT–CT non-rigid registration
✓
Dedicated brain SPECT (ring) ~3 mm; whole-body SPECT ~7-12 mm

6.1 Gamma Camera Components (Collimator, Crystal, PMT)

6.1.1 General Structure and Principle of Operation

The gamma camera (Anger camera) is the device developed by Hal Anger in 1958 that forms the basis of planar and SPECT imaging in nuclear medicine. By detecting the gamma photons emitted from the patient, it produces a two-dimensional (planar) or three-dimensional (SPECT) map of radionuclide distribution.

Basic components (in order from outside to inside):

1. Collimator → selection of direction (passes only photons at a certain angle) 2. NaI(Tl) scintillation crystal → converts the gamma photon into light photons 3. Light guide → directs the light to the PMTs 4. Photomultiplier tubes (PMT) → convert light photons into an electrical signal 5. Position circuitry → determines the X, Y coordinates (Anger logic) 6. Pulse height analyser (PHA) → energy selection (rejects scattered photons) 7. Computer and image processing system → image formation and analysis

Signal flow:

Gamma photon → passage through the collimator → scintillation in the crystal (light production) → transmission through the light guide to the PMTs → conversion to an electrical signal in the PMTs → position calculation (X, Y) → energy analysis (Z pulse) → recording in the image matrix

PMT PMT PMT PMT PMT PMT Patient 4 PMT array (37–91, hexagonal) 3 Light guide 2 NaI(Tl) crystal (3/8 inch) 1 Collimator (lead septa) 5 Positioning (Anger logic) X = Σ(Xᵢ·Sᵢ)/ΣSᵢ, Y = Σ(Yᵢ·Sᵢ)/ΣSᵢ 6 PHA: Z = ΣSᵢ (energy) in window → accepted, outside → rejected 7 Computer event (X, Y) recorded in image matrix Ray types along hole axis → reaches crystal oblique → absorbed in septum scattered in patient (lower energy) → rejected by the PHA

Figure 6.1: Gamma camera components and signal flow: from the collimator to the image matrix (schematic).

Did this figure help you understand the topic?

6.1.2 Collimator

The collimator is the first and most critical component of the gamma camera. It provides spatial information by allowing only photons from certain directions to reach the crystal. Without a collimator photons reach the crystal from every direction and no meaningful image can be formed.

Structure:

•
A perforated plate or array of parallel tubes made of a high-Z material (usually lead, sometimes tungsten)
•
The geometry of the holes (the spaces between septa) determines the collimator type
•
Septum: The lead wall between holes → absorbs unwanted photons

Role of the collimator:

•
The most important component determining the spatial resolution of the gamma camera
•
The most important component determining the sensitivity of the gamma camera
•
There is an inverse relationship (trade-off) between spatial resolution and sensitivity
•
The collimator is the weakest link of the gamma camera → it limits the total system resolution
BOARD TIP
▸
"What is the most important component determining the spatial resolution of the gamma camera?"

→ The COLLIMATOR.

▸
"What is the most important component determining the sensitivity of the gamma camera?"

→ Again the COLLIMATOR. The collimator determines both resolution and sensitivity, and there is an inverse relationship between the two. The collimator is chosen according to the clinical application! Collimator details are covered in Section 6.2.

6.1.3 NaI(Tl) Scintillation Crystal3 questions

The detector component of the gamma camera. It converts gamma photons into visible light photons (scintillation).

Physical properties (see Section 5.2 – detailed):

•
Material: Thallium-doped sodium iodide – NaI(Tl)
•
Standard thickness: 3/8 inch (~9.5 mm) → optimised for Tc-99m (140 keV)
•
Diameter: Typically 40-60 cm (rectangular or circular)
•
Density: 3.67 g/cm³
•
Effective Z: 50
•
Light output: ~38 photons/keV; the highest value among the classical scintillators
•
Decay time: ~230 ns
•
Energy resolution: ~10% (at 140 keV)
•
Hygroscopic → hermetic encapsulation required

Effects of crystal thickness:

•
Thick crystal (>3/8 inch):
–
Sensitivity increases (more photons absorbed)
–
Intrinsic spatial resolution decreases (light spreads over a wider area)
–
Preferred for high-energy radionuclides (I-131, Ga-67)
–
In a crystal of fixed thickness the intrinsic (photopeak) efficiency decreases as photon energy rises: 3/8-inch NaI(Tl) absorbs ~90% of 140 keV photons but only ~30% of the 364 keV photons of I-131
•
Thin crystal (<3/8 inch, e.g. 1/4 inch):
–
Intrinsic spatial resolution increases (light stays within a narrower area)
–
Sensitivity decreases (fewer photons absorbed)
–
May be preferred for low-energy radionuclides
•
3/8-inch standard thickness: Optimal balance for Tc-99m (140 keV) → absorbs ~90% of the photons
BOARD TIP
▸
"What is the standard crystal thickness in the gamma camera?"

→ 3/8 inch (~9.5 mm).

▸
"Why was this thickness chosen?"

→ It gives the optimal balance between sensitivity and resolution for the 140 keV photons of Tc-99m.

▸
"What happens if the crystal thickness is increased?"

→ Sensitivity↑, intrinsic resolution↓.

▸
"If it is reduced?"

→ Sensitivity↓, intrinsic resolution↑.

In a gamma camera the scintillation light spreads to the PMTs, position is found by a weighted mean and energy by the summed signal; the fraction of photons absorbed and the light spread by crystal thickness are shown.

Continuous stream · no seeking

Key point: the weighted mean of the PMT signals gives the position and their sum the energy; a thick crystal catches more photons but spreads the light wider, so the position becomes less certain.

Source: book (NaI(Tl) 3/8 inch, 3.67 g/cm³; X = Σ(Xᵢ·Sᵢ)/ΣSᵢ, Z = ΣSᵢ; Tc-99m window 126–154 keV). Absorption from the NIST XCOM NaI total attenuation coefficient (coherent included); the book's ~30% at 364 keV is the photopeak efficiency, as part of the interacting photons escape by Compton scattering. In the crystal-thickness step the side view is drawn at 2× vertical scale (light guide 12 mm). Light spot: point light source, reflections ignored, FWHM ≈ 1.53 × distance to the PMT plane. Model assumptions: 37 PMTs, 76 mm pitch, 12 mm light guide, ~930 photoelectrons at 140 keV, Poisson noise; PMTs below 10% of the largest signal ignored (like the threshold in modern cameras); scattered photons ~25% of events, 95–125 keV (illustrative).

How to use: a single click on the drawing pauses and resumes; in the crystal thickness step ↑ ↓ change the thickness, the buttons below change thickness and energy; ← → change steps.

Speed
Test yourself:Chapter 6 · question 9Chapter 5 · question 24
Did this animation help you understand the topic?

Figure 6.2: Effect of crystal thickness on light spread, intrinsic resolution and photon absorption fraction.

Signs of crystal damage:

•
Yellow discoloration (yellowing) → moisture damage (hygroscopic)
•
Deterioration of uniformity → crystal crack or moisture ingress
•
Cold spots → local crystal damage
•
Crystal damage cannot be repaired → the crystal must be replaced

6.1.4 Light Guide

The optical coupling element located between the crystal and the PMTs.

Features:

•
Usually made of glass or plastic (Lucite)
•
Transmits the light leaving the crystal homogeneously to the PMTs
•
Provides optical coupling → there must be no air gap (to prevent light loss)
•
In some modern systems no light guide is used → the crystal is coupled directly to the PMTs

6.1.5 Photomultiplier Tubes (PMT)

PMTs are vacuum tubes that convert the light photons from the crystal into an electrical signal and amplify it (see Section 5.2 – detailed).

PMT arrangement in the gamma camera:

•
Typically 37-91 PMTs are placed in a hexagonal array
•
Each PMT receives part of the light from the crystal
•
PMTs close to the scintillation point receive more light → produce a larger signal
•
As the number of PMTs increases, intrinsic spatial resolution improves

Functions of the PMT in the gamma camera:

1. Position determination: The signal size from each PMT is used to calculate the location of the scintillation point

2. Energy determination: The sum of all PMT signals (Z pulse) gives the energy of the photon

6.1.6 Position Circuitry (Anger Logic)2 questions

The positioning logic developed by Hal Anger determines the X, Y coordinates of the scintillation event in the crystal.

Principle of operation:

•
The signal from each PMT is weighted according to the position of that PMT
•
X coordinate: X = Σ(Xᵢ × Sᵢ) / Σ(Sᵢ)
•
Y coordinate: Y = Σ(Yᵢ × Sᵢ) / Σ(Sᵢ)
•
Xᵢ, Yᵢ: position of the i-th PMT
•
Sᵢ: signal size from the i-th PMT
•
This calculation is the weighted mean (centroid) method

Z pulse (energy signal):

•
Z = Σ(Sᵢ) → the sum of all PMT signals
•
The size of the Z pulse is proportional to the energy of the absorbed photon
•
The PHA evaluates the Z pulse and accepts events within the energy window
BOARD TIP
▸
"How is position determined in the gamma camera?"

→ Anger logic: the X, Y coordinates are calculated from the weighted mean of the signals from each PMT.

▸
"What is the Z pulse?"

→ The sum of all PMT signals → represents the energy of the photon.

▸
"What happens if the number of PMTs increases?"

→ Intrinsic spatial resolution improves (more precise position calculation).

In a gamma camera the scintillation light spreads to the PMTs, position is found by a weighted mean and energy by the summed signal; the fraction of photons absorbed and the light spread by crystal thickness are shown.

Continuous stream · no seeking

Key point: the weighted mean of the PMT signals gives the position and their sum the energy; a thick crystal catches more photons but spreads the light wider, so the position becomes less certain.

Source: book (NaI(Tl) 3/8 inch, 3.67 g/cm³; X = Σ(Xᵢ·Sᵢ)/ΣSᵢ, Z = ΣSᵢ; Tc-99m window 126–154 keV). Absorption from the NIST XCOM NaI total attenuation coefficient (coherent included); the book's ~30% at 364 keV is the photopeak efficiency, as part of the interacting photons escape by Compton scattering. In the crystal-thickness step the side view is drawn at 2× vertical scale (light guide 12 mm). Light spot: point light source, reflections ignored, FWHM ≈ 1.53 × distance to the PMT plane. Model assumptions: 37 PMTs, 76 mm pitch, 12 mm light guide, ~930 photoelectrons at 140 keV, Poisson noise; PMTs below 10% of the largest signal ignored (like the threshold in modern cameras); scattered photons ~25% of events, 95–125 keV (illustrative).

How to use: a single click on the drawing pauses and resumes; in the crystal thickness step ↑ ↓ change the thickness, the buttons below change thickness and energy; ← → change steps.

Speed
Test yourself:Chapter 6 · question 12
Did this animation help you understand the topic?

Figure 6.3: Anger logic: determination of position (X, Y) from the weighted mean of the PMT signals and of energy (Z) from their sum (schematic).

6.1.7 Pulse Height Analyser (PHA) and Energy Window

The PHA accepts or rejects events according to the size of the Z pulse (see Section 5.5.3 – detailed). In the gamma camera the energy window setting is critical for image quality.

Standard energy window settings:

•
Tc-99m: 140 keV ± 10% → 20% window (126-154 keV)
•
I-131: 364 keV ± 10% → 20% window (328-400 keV)
•
Tl-201: a 30% window centred on 70 keV (~60-81 keV; Hg X-rays 69-83 keV) together with a second 20% window at 167 keV
•
Ga-67: Multiple windows (93, 185, 300 keV)
•
In-111: Multiple windows (171, 245 keV)

Effect of the energy window on image quality:

•
Narrow window → scatter rejection↑ → contrast↑ → sensitivity↓
•
Wide window → sensitivity↑ → scatter↑ → contrast↓

6.2 Collimator Types and Selection

6.2.1 Parallel-Hole Collimators9 questions

The most widely used type of collimator. All holes are parallel to one another and perpendicular to the crystal surface.

Features:

•
Image size = object size (no magnification/minification)
•
Spatial resolution DECREASES as distance increases (the most important feature)
•
Sensitivity does NOT CHANGE as distance increases (stays constant)
•
The image is not inverted (orientation is preserved)

Subtypes of parallel-hole collimator:

1. Low Energy High Resolution (LEHR):

–
Energy range: <150 keV
–
Long, narrow holes → best resolution → lowest sensitivity
–
Septal thickness: Thin (sufficient for low energy)
–
Use: Bone scintigraphy (Tc-99m MDP), thyroid scintigraphy
–
The most frequently used collimator type

2. Low Energy All Purpose (LEAP) / Low Energy General Purpose (LEGP):

–
Energy range: <150 keV
–
Medium-length holes → balance between resolution and sensitivity
–
Use: Dynamic studies, renal scintigraphy, hepatobiliary scintigraphy
–
Sensitivity higher than LEHR, resolution lower than LEHR

3. Low Energy High Sensitivity (LEHS):

–
Energy range: <150 keV
–
Short, wide holes → highest sensitivity → lowest resolution
–
Use: Low-count dynamic studies, paediatric applications

4. Medium Energy (ME):

–
Energy range: 150-300 keV
–
Thick septa → prevent septal penetration by higher-energy photons
–
Use: Ga-67 (93, 185, 300 keV), In-111 (171, 245 keV)

5. High Energy (HE):

–
Energy range: ~300-400 keV (ultra-high-energy/UHE collimator for 511 keV)
–
Thickest septa → lowest resolution and sensitivity
–
Use: I-131 (364 keV), F-18 (511 keV – imaging a PET agent with SPECT)
BOARD TIP
▸
Collimator selection is a classic board exam topic. Basic rule: a collimator suited to the energy of the radionuclide must be chosen. If a high-energy radionuclide is imaged with a low-energy collimator → septal penetration → star artefact → image quality deteriorates seriously.
▸
"Collimator for Tc-99m?"

→ LEHR or LEAP.

▸
"Collimator for Ga-67?"

→ ME.

▸
"Collimator for I-131?"

→ HE.

LEHR <150 keV Bone, thyroid (most common) LEAP / LEGP <150 keV Dynamic, renal, hepatobiliary LEHS <150 keV Low-count dynamic, paediatric ME 150–300 keV Ga-67, In-111 HE ~300–400 keV I-131 (511 keV: UHE) view cone LEHR → LEHS: holes shorter/wider → sensitivity ↑, resolution ↓ energy ↑ → thicker septa (penetration ↓; resolution and sensitivity ↓)

Figure 6.4: Subtypes of parallel-hole collimator: effect of hole length, diameter and septal thickness on sensitivity and resolution (schematic).

Did this figure help you understand the topic?

Design parameters of the parallel-hole collimator:

•
Hole length (L): Long hole → resolution↑, sensitivity↓
•
Hole diameter (d): Narrow hole → resolution↑, sensitivity↓
•
Geometric efficiency ≈ K²·d⁴ / [L²·(d+t)²]. When the hole diameter is doubled, sensitivity increases approximately 4-fold while resolution deteriorates approximately 2-fold (Rc ∝ d); in other words, sensitivity is roughly proportional to Rc²
•
Septal thickness (t): Thick septa → penetration↓, sensitivity↓
•
Hole shape: Round, square or hexagonal (hexagonal most common)

Collimator resolution formula (parallel-hole):

Rc = d × (L + z) / L

•
Rc: Collimator resolution (FWHM)
•
d: Hole diameter
•
L: Hole length
•
z: Source-collimator distance
–
→ As distance (z) increases Rc increases (worsens) → the closer the source is to the collimator, the better the resolution

WHY IT MATTERS · Septal penetration criterion

See the animation: Figure 6.5 →

•
What it is: A collimator is designed so that no more than 5% of photons pass through the shortest septal path between two neighbouring holes; septal thickness is chosen according to photon energy (the linear attenuation coefficient μ of lead): t ≥ (6d/μ) / (L − 3/μ).
•
In numbers: The μ of lead is ~27/cm at 140 keV and ~3/cm at 364 keV, so the thin septa of a low-energy collimator cannot stop I-131. Besides its 159 keV photon, I-123 has high-energy photons with a total intensity of ~2.6% (the strongest 529 keV, 1.3%).
•
Why it matters clinically: With a collimator not matched to the energy, septa are penetrated: star artefacts appear on post-therapy I-131 images; in I-123 MIBG, high-energy photons from liver and lung penetrate the septa, scatter into the 159 keV window and change the heart-to-mediastinum ratio. In a phantom study a medium-energy collimator reduced this effect; for quantitative comparison the collimator type is stated in the report.
•
In the exam: "What determines septal thickness?" → Photon energy, so that septal penetration does not exceed 5%.
•
Sources: Cherry, Sorenson and Phelps, Physics in Nuclear Medicine 2012; Verberne et al., Eur J Nucl Med Mol Imaging 2005; NIST XCOM; ENSDF.

6.2.2 Pinhole Collimator4 questions

A collimator type consisting of a single small hole (aperture). It works on the principle of the camera obscura.

Features:

•
The image is inverted (left-right and top-bottom)
•
If the object is close to the focal point → magnification
•
If the object is far from the focal point → minification
•
Magnification factor: M = f / z (f: pinhole-crystal distance, z: object-pinhole distance)
•
Resolution improves as the object comes closer
•
Sensitivity increases as the object comes closer
•
Ideal for high-resolution imaging of small organs
•
Magnification (M) reduces the contribution of intrinsic resolution in the object plane to Ri/M; for this reason, for objects close to the camera, the resolution of a system with a pinhole (and converging) collimator can be even better than the intrinsic resolution of the camera

Clinical use:

•
Thyroid scintigraphy → the most classic use
•
Paediatric hip (Legg-Calvé-Perthes disease)
•
Small joints
•
Parathyroid scintigraphy (in some centres)

Pinhole collimator aperture size:

•
Small aperture → resolution↑, sensitivity↓
•
Large aperture → sensitivity↑, resolution↓
•
Typical aperture size: 3-6 mm
BOARD TIP
▸
"What does the image look like with a pinhole collimator?"

→ INVERTED (left-right and top-bottom).

▸
"The most classic use of the pinhole collimator?"

→ Thyroid scintigraphy.

▸
"When does magnification occur with a pinhole collimator?"

→ When the object is close to the focal point. A thyroid scintigraphy image may be shown in the board exam with the question "which collimator was used?" → Pinhole (clue: inverted image).

6.2.3 Converging Collimator2 questions

The holes are angled so that they converge to a point in front of the crystal surface (fan-beam or cone-beam).

•
Fan-beam: The holes converge in one axis and are parallel in the other (axial) axis → magnification occurs in one dimension. In cone-beam the holes meet at a single focus in both axes

Features:

•
The image is magnified (the object is projected larger on the crystal → magnification)
•
Sensitivity is higher than with a parallel-hole collimator
•
Resolution is close to that of the parallel-hole collimator
•
The image is not inverted
•
The field of view (FOV) decreases with depth

Clinical use:

•
Brain SPECT (fan-beam collimator)
•
Cardiac SPECT (in some systems)
•
Imaging of small organs with high sensitivity

6.2.4 Diverging Collimator

The holes are angled so that they diverge away from the crystal surface.

Features:

•
The image is minified
•
The field of view (FOV) widens → large organs fit onto a small crystal
•
Sensitivity and resolution are lower than with a parallel-hole collimator
•
Its use has declined now that large-crystal cameras have become widespread

Clinical use (historical):

•
Lung or whole-body imaging with small-crystal cameras

6.2.5 Collimator Types – Comparative Summary2 questions

•
Parallel-hole: No magnification | Image not inverted | Most common | Distance↑ → resolution↓, sensitivity constant
•
Pinhole: Magnification (when close) | Image INVERTED | Thyroid | Distance↑ → resolution↓, sensitivity↓
•
Converging: Magnification | Image not inverted | Brain SPECT | Sensitivity > parallel
•
Diverging: Minification | Image not inverted | FOV enlargement | Rare today
BOARD TIP
▸
The collimator comparison is a board classic. Memorise: "The only collimator that inverts the image?" → Pinhole.
▸
"Collimators that magnify?"

→ Pinhole and converging.

▸
"Collimator that minifies?"

→ Diverging.

▸
"Collimator whose sensitivity does not change with distance?"

→ Parallel-hole.

▸
"Collimator whose resolution and sensitivity both decrease with distance?"

→ Pinhole.

Photons from an object are selected by the collimator and those passing form the image in the crystal; parallel-hole, pinhole, converging and diverging collimators and the effect of source–collimator distance are shown.

Continuous stream · no seeking

Key point: the collimator sets the image geometry; with a parallel-hole collimator resolution worsens with distance while sensitivity stays the same; a pinhole inverts the image and magnifies nearby objects.

Source: book; LEHR d = 1.5 mm, L = 35 mm (manufacturer value), Ri = 3.5 mm; Rc = d·(L + z)/L, Rs = √(Ri² + Rc²); pinhole M = f/z, f = 20 cm example value. Photon numbers and angles not to scale. Septa step: LEHR 1.5 / 0.2 / 35 mm and MEGP 3.0 / 1.05 / 58 mm (GE Discovery; Wright et al., Phys Med Biol 2017), HE 4.0 / 2.0 / 59.7 mm (Siemens Symbia); lead attenuation coefficients from NIST XCOM. This is a 2D cross-section simulation; true (3D) penetration fractions differ (Monte Carlo: LEHR + I-131 ~50%, HEGP + I-131 ~18%; Sawant et al., J Nucl Med Technol 2025).

How to use: a single click on the drawing pauses and resumes; in the distance steps drag the object or use ← → to move it closer or farther; in the septa step ↑ ↓ change the radionuclide.

Speed
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Figure 6.5: Collimator types and their effect on image magnification/minification and inversion (schematic).

6.3 Energy Window and Pulse Height Analyser

6.3.1 Role of the PHA in the Gamma Camera

The PHA (pulse height analyser) performs energy selection in the gamma camera, rejecting scattered photons and increasing image contrast (see Section 5.5.3 – basic principles).

Function of the PHA in the gamma camera:

•
Evaluates the size of the Z pulse
•
Accepts events within the set energy window
•
Rejects events outside the window (scattered photons, background)
•
Directly affects image contrast and quality

6.3.2 Single and Multiple Energy Windows

Single-window applications:

•
Tc-99m: 140 keV ± 10% (20% window)
•
I-131: 364 keV ± 10% (20% window)

Multiple-window applications:

•
Tl-201: 70 keV window + 167 keV window
•
Ga-67: 93 keV + 185 keV + 300 keV (three windows)
•
In-111: 171 keV + 245 keV (two windows)

Dual-isotope studies:

•
Simultaneous Tl-201 + Tc-99m imaging: Separate images are obtained in different energy windows
•
Tc-99m pertechnetate + Tc-99m MIBI parathyroid subtraction technique: same radionuclide, different radiopharmaceuticals → sequential imaging
•
General rule when two radionuclides are used on the same day: the lower-energy radionuclide is given first, then the higher-energy one. This prevents higher-energy photons from scattering into the low-energy window (downscatter/spilldown) (e.g. Xe-133 ventilation first, then Tc-99m MAA perfusion)

6.3.3 Scatter Correction Windows

Additional energy windows can be used to estimate and correct scatter:

Triple Energy Window (TEW) method:

•
Main window: Photopeak window (e.g. 126-154 keV)
•
Lower window: Narrow window below the photopeak (e.g. 120-126 keV)
•
Upper window: Narrow window above the photopeak (e.g. 154-160 keV)
•
Scatter is estimated from the lower and upper windows → subtracted from the main window
BOARD TIP
▸
"How many energy windows are used in Ga-67 imaging?"

→ 3 windows (93, 185, 300 keV).

▸
"For In-111?"

→ 2 windows (171, 245 keV).

▸
"For Tl-201?"

→ 2 windows (70 keV and 167 keV). Using multiple windows increases sensitivity but makes scatter management more difficult.

A Tc-99m: 20% window and TEW 50 75 100 125 150 175 200 Energy (keV) Counts lower window 120–126 upper window 154–160 photopeak window 140 keV ± 10% (126–154 keV) scatter photons B Multiple windows (schematic) Ga-67 93 185 300 In-111 171 245 Tl-201 70 167 70 keV: Hg X-rays (69–83 keV) 100 200 300 Energy (keV)

Figure 6.6: Tc-99m photopeak window and triple energy window (TEW) scatter correction; radionuclides using multiple windows (schematic).

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6.4 SPECT Principle and Acquisition

6.4.1 Basic Principle of SPECT2 questions

SPECT (Single Photon Emission Computed Tomography) works on the principle that the gamma camera rotates around the patient, collecting projection images from different angles, and three-dimensional (3D) tomographic images are formed from these projections.

Planar imaging vs SPECT:

•
Planar: 2D projection → superimposed structures → low contrast → lesion detection difficult
•
SPECT: 3D tomographic → structures in separate slices → high contrast → lesion detection easy
•
SPECT substantially improves contrast resolution compared with planar imaging

SPECT vs PET comparison:

•
SPECT: Single-photon detection → collimator required → low sensitivity → spatial resolution 8-12 mm
•
PET: Coincidence detection → no collimator needed (electronic collimation) → high sensitivity → spatial resolution 4-6 mm
•
The sensitivity of PET is ~10-100 times higher than that of SPECT

SPECT system geometries:

•
General-purpose SPECT: There are two detectors on a rotating gantry; the detectors are placed opposite each other at 180° (whole body, bone, brain) or at 90° (L-mode, cardiac)
•
In PET the direction of the photon is determined by electronic coincidence ("electronic collimation"); in SPECT this is done by a physical collimator made of lead or tungsten
•
In SPECT the photon energy varies with the radionuclide used (from approximately 70 keV for Tl-201 to above 350 keV for I-131); in PET it is always 511 keV
•
Dedicated brain SPECT systems in ring geometry aim to reach a spatial resolution of ~3 mm; in whole-body SPECT systems this value is ~7-12 mm

6.4.2 SPECT Acquisition Parameters6 questions

Detector configuration:

•
Single-head: 360° rotation needed → long duration → rare today
•
Dual-head: The most common configuration
•
180° configuration: Detectors opposite each other (180°) → a 180° rotation is enough to collect 360° of data
•
90° configuration (L-mode): Detectors at 90° → preferred for cardiac SPECT
•
Triple-head: Higher sensitivity → rare today

Rotation angle:

•
360° acquisition: General SPECT applications (bone, brain, lung)
–
More homogeneous sampling → fewer artefacts
–
Longer duration
•
180° acquisition: Cardiac SPECT
–
RAO 45° → LPO 45° (right anterior oblique → left posterior oblique)
–
Because the heart lies anteriorly and to the left, this angular range is sufficient
–
Shorter duration → patient comfort↑
–
Attenuation is high in the posterior projections → 180° is preferred
•
Disadvantage: Resolution varies with distance → the anterior wall is imaged with better resolution (close to the collimator) and the inferior wall with worse resolution (far from the collimator)
•
Disadvantage: Geometric distortion may occur because of incomplete angular sampling
•
Advantage: The high attenuation in the posterior projections is eliminated → better image quality

Number of projections (stops):

•
Typically 60-128 projections (in a 360° acquisition)
•
Cardiac SPECT: 32-64 projections (in a 180° acquisition)
•
More projections → better angular sampling → better reconstruction quality → longer duration
•
Minimum number of projections: Should satisfy the Nyquist sampling theorem

Time per projection:

•
Typically 15-40 seconds/projection
•
As time increases counts increase → noise decreases → image quality improves → total acquisition time lengthens
•
The risk of patient motion increases with time → an optimal balance is needed

Matrix size:

•
64 × 64: Cardiac SPECT, low-count studies
•
128 × 128: Bone SPECT, brain SPECT, general purpose
•
Larger matrix → better spatial sampling → more counts needed (noise may increase)
•
The pixel size should be 1/3-1/2 of the spatial resolution (Nyquist criterion)

Rotation type:

•
Step-and-shoot: The detector stops at set angles → acquires data → rotates to the next angle
–
The most widely used mode
•
Advantage: Stable data acquisition at each stop
•
Disadvantage: No data are acquired during rotation → loss of time
•
Continuous rotation: The detector rotates continuously and acquires data simultaneously
•
Advantage: Shorter total duration
•
Disadvantage: Angular blurring → loss of resolution

Detector orbit:

•
Circular orbit:
–
Fixed radius → easy to implement
•
Disadvantage: Because the body is elliptical, the detector stays far from the body at some angles → loss of resolution
•
Body-contour orbit (non-circular orbit):
–
The detector rotates as close as possible to the body at every angle
•
Advantage: Minimum distance at all angles → optimal resolution
–
Preferred in cardiac and general SPECT
BOARD TIP
▸
"Rotation angle in cardiac SPECT?"

→ 180° (RAO 45° → LPO 45°).

▸
"Why not 360°?"

→ Attenuation in the posterior projections is very high → it degrades image quality.

▸
"Detector configuration in cardiac SPECT?"

→ 90° (L-mode) dual-head.

▸
"Rotation angle in brain SPECT?"

→ 360°.

▸
"Why is the body-contour orbit preferred?"

→ The detector-patient distance is minimised → resolution is optimised.

Gamma camera heads rotating around a thoracic cross-section: 180° opposed and L-mode configurations, the angles acquired, and system resolution on circular and body-contour orbits are shown.

Continuous stream · no seeking

Key point: two opposed heads collect 360° of data in a 180° rotation; in cardiac imaging L-mode covers only the anterior 180° near the heart; a body-contour orbit keeps the detector close to the patient and preserves resolution.

Source: book (dual head 180°/90°, cardiac RAO 45° → LPO 45°, 60–128 projections over 360° and 32–64 for cardiac, 15–40 s per projection). Example: 128 and 64 projections, 20 s per projection, rotation time excluded. Body section 36 × 24 cm (illustrative), collimator 1.5 cm from the body. Resolution with the LEHR values of the collimator animation: Rc = d·(L + z)/L, Rs = √(Ri² + Rc²) (d 1.5 mm, L 35 mm, Ri 3.5 mm). Drawing to scale; heads with 40 cm field of view.

How to use: a single click on the drawing pauses and resumes; in the orbit step ↑ ↓ switch between the circular and the body-contour orbit; ← → change steps.

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Figure 6.7: SPECT acquisition: 180° opposed and 90° (L-mode) detector configurations, with circular and body-contour orbits (schematic).

6.4.3 SPECT Reconstruction

SPECT reconstruction is the process of forming tomographic slice images from the acquired projection data (see Chapter 8 – detailed).

Basic methods:

•
Filtered Back Projection (FBP): Fast, analytical method → star artefact → corrected with a filter
•
Iterative reconstruction (OSEM, MLEM): Slow but more accurate → attenuation, scatter and resolution corrections can be included → the standard today

Corrections in SPECT:

•
Attenuation correction (AC): CT-based (SPECT/CT) or the Chang method
•
Scatter correction (SC): TEW or model-based
•
Resolution correction (RC / PSF recovery): Compensates for distance-dependent loss of resolution
•
Motion correction: Reduces patient motion artefacts

6.4.4 SPECT Image Orientation

Cardiac SPECT slice planes:

•
Short axis (SA): Perpendicular to the long axis of the heart → ring-shaped slices
•
Vertical long axis (VLA): Parallel to the long axis of the heart, sagittal plane → 2-chamber view
•
Horizontal long axis (HLA): Parallel to the long axis of the heart, coronal plane → 4-chamber view

General SPECT slice planes:

•
Transaxial (axial)
•
Coronal
•
Sagittal
BOARD TIP
▸
"Which slice planes are used in cardiac SPECT?"

→ Short axis (SA), vertical long axis (VLA), horizontal long axis (HLA). These planes are reoriented according to the anatomical axis of the heart (reorientation). A slice image may be shown in the board exam with the question "which plane?".

A 3D model of the left ventricle: the oblique appearance of transaxial slices due to the tilted long axis, reorientation by two angles, and SA, VLA and HLA slices are shown.

Continuous stream · no seeking

Key point: the heart's long axis is oblique to the body axes, so transaxial slices cut the left ventricle obliquely; the data are reoriented to the long axis and SA, VLA and HLA slices are taken relative to it.

Source: book (SA perpendicular to the long axis, ring; VLA sagittal, 2-chamber; HLA coronal, 4-chamber; reorientation). Model: left ventricle as a half-ellipsoid shell, illustrative adult dimensions (outer radius 3.4 cm, base to apex 8.5 cm, wall ~1.1 cm); the long axis points ~45° left of the sagittal plane and ~30° below the horizontal (illustrative, varies between patients). Right ventricle and atria not drawn. Slices computed from the model; colour shows tracer uptake.

How to use: a single click on the drawing pauses and resumes; in the third step ↑ ↓ change the slice plane (SA / VLA / HLA); ← → change steps.

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Figure 6.8: Cardiac SPECT slice planes: short axis (SA), vertical long axis (VLA) and horizontal long axis (HLA) (schematic).

6.5 SPECT/CT Hybrid Imaging

6.5.1 Basic Principle of SPECT/CT2 questions

SPECT/CT is a hybrid imaging system in which a SPECT gamma camera and a diagnostic or low-dose CT are integrated on the same gantry. SPECT provides functional information, while CT provides anatomical information and an attenuation correction map.

Advantages of SPECT/CT:

1. Anatomical localisation: Determines the exact anatomical location of SPECT findings 2. CT-based attenuation correction (CTAC): More accurate quantitative assessment 3. Increased diagnostic confidence: Distinction between physiological and pathological uptake 4. Fewer false positives: Specificity increases with anatomical correlation 5. Fewer false negatives: Sensitivity increases with attenuation correction

History:

•
One of the first hybrid SPECT/CT cameras was developed by Hasegawa and colleagues
•
The first commercial SPECT/CT system was introduced in 1999 by GE Healthcare. The system had a low-dose single-slice CT with a resolution of ~3.5 mm that scanned the full field of view in ~10 minutes (SPECT resolution ~10-15 mm)
•
Acquiring SPECT and CT on separate devices and matching them by software has had limited success because of patient and organ motion, even when external positioning is done correctly
•
Current systems include high-resolution, fast diagnostic CT; the two examinations are performed in the same session and the total time is shortened
•
Example: High-resolution CT distinguishes much better than SPECT whether an uptake in the spine belongs to the bone or to an adjacent joint

6.5.2 The CT Component of SPECT/CT3 questions

Types of CT:

•
Low-dose CT (non-diagnostic):
–
Only for attenuation correction and anatomical localisation
–
Low tube current (mA) → low radiation dose
–
Not of diagnostic quality → fine detail is not seen
–
Standard on most SPECT/CT systems
•
Full diagnostic CT:
–
High-quality anatomical imaging
–
Contrast-enhanced studies can be performed
–
Provides additional diagnostic information
–
Higher radiation dose
–
Available on some high-end SPECT/CT systems

SPECT/CT radiation dose:

•
The effective dose in SPECT/CT is higher than with SPECT alone; the contribution of CT is ~1-10 mSv depending on the region examined
•
For localisation and attenuation correction, a low-mAs CT of a few mSv is sufficient in most cases
•
The CT protocol should be chosen according to the diagnostic aim; the benefit of the additional information must outweigh the radiation risk (justification)

Principle of CT attenuation correction (CTAC):

•
The linear attenuation coefficient (µ) of each voxel is calculated from the CT images
•
CT Hounsfield unit (HU) values are converted into µ values appropriate to the SPECT photon energy (energy scaling)
•
This µ map is used for attenuation correction in SPECT reconstruction
•
CT and SPECT operate at different energies → a bilinear scaling algorithm is needed
•
Definition of HU: HU = [(µtissue − µwater) / µwater] × 1000; the µ value depends on the atomic composition of the tissue and on the photon energy
•
CT uses a polyenergetic X-ray spectrum whereas SPECT usually works at a single photon energy; HU values are therefore converted to µ with a bilinear transformation determined with a phantom
•
In attenuation correction the length of each projection line and how µ varies along the line are calculated from the CT data; the correction factor equals the reciprocal of the probability that the photon passes through
•
Scatter correction: Commercial systems mostly use additional energy windows (e.g. TEW). If these windows do not fully reflect the scatter in the primary window, analytical or Monte Carlo-based modelling is used; the main inputs of the model are patient size and internal tissue distribution
BOARD TIP
▸
"What are the two basic functions of CT in SPECT/CT?"

→ 1) Anatomical localisation, 2) Attenuation correction (CTAC).

▸
"How does CTAC work?"

→ The HU values obtained from CT are converted into attenuation coefficients appropriate to the SPECT photon energy → an attenuation map is created → used in SPECT reconstruction.

6.5.3 SPECT/CT Registration and Artefacts6 questions

Registration:

•
SPECT and CT images are acquired sequentially on the same gantry → hardware registration
•
If the patient moves between the two acquisitions → misregistration artefact
•
Respiratory motion → misregistration in the region of the diaphragm

Artefacts specific to SPECT/CT:

•
Misregistration artefact: SPECT-CT mismatch → wrong anatomical localisation and incorrect attenuation correction
•
Metallic implant artefact: Streak artefact on CT → falsely high HU → overcorrection for attenuation → hot artefact (spuriously increased uptake)
•
CT contrast artefact: IV or oral contrast → high HU → overcorrection for attenuation → hot artefact
•
Truncation artefact: If the patient extends outside the CT FOV → edge artefacts
•
Respiratory artefact: CT instantaneous (inspiration/expiration), SPECT averaged → mismatch at the level of the diaphragm

Other causes of misregistration and artefacts:

•
Data acquisition in SPECT, lasting 15-25 seconds per projection, represents the average of respiration; fast CT captures a random moment of the respiratory cycle
•
Differences between the axial centres of the SPECT and CT fields of view and sagging of the low-Z patient table (especially in obese patients) disturb the alignment of the two modalities
•
Beam hardening: Low-energy X-ray photons are attenuated more; attenuation therefore appears lower than it is in the centre of the object on CT
•
In large patients scanned with the arms down, the CT field of view does not fully cover the body (truncation) → attenuation correction remains incomplete
•
In very large patients, the photon count is insufficient along long, highly attenuating paths in low-dose CT → high-HU streak artefacts appear
•
The resolution difference between SPECT and CT causes counts to spill into regions with no activity. Applying a Gaussian filter to the CT can equalise the two resolutions; however, this does not remove respiration-related differences
•
Iodinated contrast increases the information provided by CT, but a high contrast density may cause the activity to be overestimated
•
The very high HU values of metal implants distort the grey scale; applying a gamma correction in display (e.g. 0.3) allocates more grey levels to the low-HU range

6.5.4 Clinical Applications of SPECT/CT

Main indications:

•
Bone SPECT/CT: Distinguishing benign from malignant lesions, stress fracture, facet arthropathy, spondylolysis
•
Parathyroid SPECT/CT: Exact anatomical localisation of the adenoma, ectopic parathyroid
•
Thyroid I-131 SPECT/CT: Distinguishing thyroid remnant from lymph node metastasis
•
Myocardial perfusion SPECT/CT: CT attenuation correction → reduces attenuation artefacts
•
Sentinel lymph node SPECT/CT: Preoperative anatomical localisation
•
Infection/inflammation: Labelled leucocyte SPECT/CT → exact localisation of the focus of infection
•
V/Q SPECT/CT: Increased accuracy in the diagnosis of pulmonary embolism
BOARD TIP
▸
"What is the most important contribution of SPECT/CT?"

→ Anatomical localisation and attenuation correction.

▸
"What does a metallic implant do in SPECT/CT?"

→ Streak artefact on CT → falsely high HU → overcorrection for attenuation → spurious hot artefact on SPECT.

▸
"Does IV contrast cause a problem in SPECT/CT?"

→ Yes, by the same mechanism → overcorrection for attenuation → hot artefact. Solution: use non-contrast CT or acquire the CT before contrast.

A CT-based attenuation correction (CTAC) CT image (HU values) Energy scaling (bilinear conversion) µ map (SPECT photon energy) in SPECT reconstruction attenuation correction B SPECT/CT artefacts Metal implant Streaks on CT falsely high HU attenuation overcorrection spurious HOT focus IV / oral contrast high HU attenuation overcorrection spurious HOT focus Patient motion / respiration misregistration (diaphragm level) wrong localisation, incorrect correction edge/diaphragm mismatch Truncation (outside CT FOV) incomplete µ map insufficient attenuation correction edge artefact

Figure 6.9: The CT-based attenuation correction chain and the mechanisms of SPECT/CT artefacts (schematic).

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6.5.5 Quantitative SPECT/CT and Patient-Specific Dosimetry2 questions

When attenuation, scatter and resolution corrections are applied, activity concentration (Bq/mL) can be measured with SPECT/CT and dosimetry can be performed in radionuclide therapies.

Volume definition and partial volume:

•
The resolution of SPECT is approximately ten times lower than that of CT → it is difficult to draw ROIs/VOIs in areas of low uptake
•
VOIs drawn on correctly registered CT can be transferred to the SPECT images; the main parameters of the absorbed dose calculation are organ volume and mass
•
Because resolution is limited, counts spill outside (spill-out) or into (spill-in) the VOI boundary
•
Recovery factors are obtained from geometries of known volume and activity (e.g. spheres); however, factors derived from spheres may not fully correct spill in irregularly shaped tumours

Patient-specific dosimetry:

•
In therapies with radionuclides emitting charged particles, normal tissues outside the target may also be damaged; treatment should therefore be optimised on the basis of dosimetry
•
Mean organ absorbed doses can be calculated from quantitative SPECT series acquired at different times; using a Monte Carlo transport program and the body composition obtained from CT, patient-specific doses can also be found at the voxel level
•
Patient motion between successive time points leads to misregistration. Because SPECT data are noisy, the non-rigid transformation is calculated from CT–CT registration and applied to the SPECT–SPECT images
•
The resolution difference may cause the local absorbed dose to be artificially overestimated in low-mass lung voxels
•
In the quantitative planar conjugate-view (geometric mean) method, the map needed for attenuation correction can be derived from the planar X-ray scout image of the SPECT/CT
BOARD TIP
▸
The four basic corrections of quantitative SPECT/CT: attenuation (CT-based µ map), scatter (energy window or Monte Carlo), resolution/partial volume (recovery) and calibration (Bq/count). In dosimetry VOIs are drawn on CT and transferred to SPECT; successive time points are aligned by CT–CT registration.

6.6 Gamma Camera Performance Parameters

6.6.1 Spatial Resolution2 questions

Spatial resolution is the ability to distinguish two close points from each other. It is measured as the FWHM (full width at half maximum). Smaller FWHM = better resolution.

Components of spatial resolution:

1. Intrinsic resolution (Rᵢ):

–
The resolution of the crystal + PMT + electronics alone, without the collimator
–
Typical value: 3-4 mm
–
Influencing factors:
–
Crystal thickness: Thin crystal → better intrinsic resolution
–
Number of PMTs: More PMTs → better intrinsic resolution
–
PMT size: Small PMTs → better intrinsic resolution
–
Photon energy: Higher energy → better intrinsic resolution (more light photons → better statistics)

2. Collimator resolution (Rc):

–
Resolution depending on the geometric properties of the collimator
–
Typical value: 6-12 mm (depending on distance)
–
Influencing factors:
–
Hole diameter: Narrow hole → better resolution
–
Hole length: Long hole → better resolution
–
Source-collimator distance: Short distance → better resolution
–
Collimator resolution is usually worse than intrinsic resolution → the collimator is the component limiting total resolution

3. Total (system) resolution (Rₛ):

Rs = √(Rᵢ² + Rc²)

•
Total resolution is always worse than its components
•
The worst component (usually the collimator) dominates total resolution

Methods of measuring spatial resolution:

•
Line source: Line spread function (LSF) → FWHM measurement
•
Bar phantom: Visual assessment → the smallest bar spacing that can be distinguished
•
Point source: Point spread function (PSF) → FWHM measurement
BOARD TIP
▸
"The component limiting the total spatial resolution of the gamma camera?"

→ The COLLIMATOR (Rc is usually much larger than Rᵢ).

▸
"Total resolution formula?"

→ Rs = √(Rᵢ² + Rc²).

▸
"What is done to improve intrinsic resolution?"

→ Thin crystal, more/smaller PMTs.

▸
"To improve collimator resolution?"

→ Long/narrow holes, short distance.

6.6.2 Sensitivity

Sensitivity is the parameter showing what fraction of the photons emitted by the source is detected. It is expressed in cps/MBq or cps/µCi.

Factors affecting sensitivity:

•
Collimator geometry: The most important factor
–
Wide/short holes → sensitivity↑ (more photons pass)
–
Narrow/long holes → sensitivity↓ (fewer photons pass)
•
Crystal thickness: Thick crystal → sensitivity↑
•
Energy window width: Wide window → sensitivity↑
•
With a parallel-hole collimator: Sensitivity is independent of distance (constant)
•
With a pinhole collimator: Sensitivity decreases with distance (similar to the inverse square law)

Photons from an object are selected by the collimator and those passing form the image in the crystal; parallel-hole, pinhole, converging and diverging collimators and the effect of source–collimator distance are shown.

Continuous stream · no seeking

Key point: the collimator sets the image geometry; with a parallel-hole collimator resolution worsens with distance while sensitivity stays the same; a pinhole inverts the image and magnifies nearby objects.

Source: book; LEHR d = 1.5 mm, L = 35 mm (manufacturer value), Ri = 3.5 mm; Rc = d·(L + z)/L, Rs = √(Ri² + Rc²); pinhole M = f/z, f = 20 cm example value. Photon numbers and angles not to scale. Septa step: LEHR 1.5 / 0.2 / 35 mm and MEGP 3.0 / 1.05 / 58 mm (GE Discovery; Wright et al., Phys Med Biol 2017), HE 4.0 / 2.0 / 59.7 mm (Siemens Symbia); lead attenuation coefficients from NIST XCOM. This is a 2D cross-section simulation; true (3D) penetration fractions differ (Monte Carlo: LEHR + I-131 ~50%, HEGP + I-131 ~18%; Sawant et al., J Nucl Med Technol 2025).

How to use: a single click on the drawing pauses and resumes; in the distance steps drag the object or use ← → to move it closer or farther; in the septa step ↑ ↓ change the radionuclide.

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Figure 6.10: Effect of source–collimator distance on system resolution and sensitivity (parallel-hole and pinhole collimators).

Sensitivity-resolution relationship:

•
There is an inverse relationship between sensitivity and spatial resolution
•
Sensitivity is sacrificed to improve resolution, and vice versa
•
Collimator selection determines this balance:
•
LEHR: Best resolution, lowest sensitivity
•
LEHS: Best sensitivity, lowest resolution
•
LEAP: Intermediate balance

6.6.3 Uniformity5 questions

Uniformity is the ability of the gamma camera to respond equally over its entire surface to a homogeneous radioactive source. It is the most important daily quality control parameter of the gamma camera.

Types of uniformity:

•
Intrinsic uniformity: Measured without the collimator, with a point source
•
System (extrinsic) uniformity: Measured with the collimator fitted, with a flood source

Uniformity measurement parameters:

•
Integral uniformity: Over the whole useful field of view (UFOV) or the central field of view (CFOV)
–
Integral uniformity (%) = [(Max pixel - Min pixel) / (Max pixel + Min pixel)] × 100
–
NEMA: The UFOV is the useful field of view specified by the manufacturer; the CFOV is the central area limited to 75% of the linear dimensions of the UFOV. Before calculation the data are smoothed with a 9-point filter
•
Differential uniformity: Maximum variation over small regions (5 pixels)

Acceptable values (NEMA standards):

•
Intrinsic integral uniformity: 3-5% (UFOV), 2-3% (CFOV)
•
System integral uniformity: 5% (UFOV)

Causes of non-uniformity:

•
PMT failure or gain drift → hot or cold area
•
Crystal damage (crack, moisture) → cold area
•
Collimator damage (crushing, deformation) → local non-uniformity
•
Energy window shift (drift) → general non-uniformity
•
Electronic failure → various patterns
BOARD TIP
▸
"The most important daily quality control test of the gamma camera?"

→ UNIFORMITY.

▸
"How is intrinsic uniformity measured?"

→ The collimator is REMOVED and a point source (Tc-99m) is used.

▸
"How is system uniformity measured?"

→ The collimator is FITTED and a flood source is used.

▸
"The most common cause of non-uniformity?"

→ PMT gain drift.

6.6.4 Energy Resolution

Energy resolution is the ability of the gamma camera to distinguish photons of different energies from one another (see Section 5.5.2 – detailed).

Energy resolution in the gamma camera:

•
Typical value with a NaI(Tl) crystal: ~10% (at 140 keV)
•
Energy resolution (%) = (FWHM / E₀) × 100
•
Better energy resolution → better scatter rejection → better image contrast

Factors affecting energy resolution:

•
Crystal light output
•
PMT quantum efficiency
•
Statistical fluctuations (the most important factor)
•
Electronic noise

6.6.5 Count Rate Performance1 questions

The ability of the gamma camera to work accurately at high count rates.

Dead time and count loss:

•
The gamma camera is a paralysable (extendable) system
•
At high count rates → dead-time losses → loss of counts
•
At very high count rates → paralysis (paradoxical fall in counts)
•
Dead time of the gamma camera: ~2-8 µs (at system level)

Count rate performance parameters:

•
Observed count rate: The count actually recorded
•
True count rate: After dead-time correction
•
20% loss count rate: The rate at which the observed count deviates by 20% from the true count → an indicator of system performance

High count rate situations:

•
First-pass studies → bolus injection → momentarily high counts
•
High-dose studies
•
Solution: Dead-time correction, appropriate dose adjustment
0 25 50 75 100 125 150 175 200 0 50 100 150 200 250 300 350 400 450 True count rate (kcps) Observed count rate (kcps) maximum observed rate (1/eτ ≈ 74 kcps) 20% loss point (observed = 0.8 × true) paralysis: as true rate rises observed count FALLS Ideal (no loss) Paralysable system (gamma camera) dead time τ = 5 µs (representative)

Figure 6.11: Relationship between true and observed count rate in the gamma camera as a paralysable system; the 20% loss point.

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6.6.6 Spatial Linearity2 questions

Spatial linearity is the ability of the gamma camera to image a straight line as straight.

Measurement method:

•
A parallel-line bar phantom or an orthogonal-hole phantom is used
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The straightness and equal spacing of the lines are assessed

Causes of non-linearity:

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Gaps between PMTs → local distortion
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Differences in PMT gain
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Non-linearity at the crystal edges (edge packing)

Correction:

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Linearity correction map → software correction
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Linearity correction must be performed BEFORE uniformity correction
BOARD TIP
▸
"Order of corrections in the gamma camera?"

→ FIRST energy correction → THEN linearity correction → LAST uniformity correction. This order matters because energy and position errors are carried into the uniformity map. If uniformity is corrected before linearity → an artefact appears.

1 Energy correction PMT/position-dependent energy differences removed 2 Linearity correction position distortion (linearity map) 3 Uniformity correction residual sensitivity differences (flood map) Because energy and position errors are carried into the uniformity map, uniformity correction is done LAST.

Figure 6.12: Order in which corrections are applied in the gamma camera: energy, linearity and uniformity (schematic).

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6.6.7 Performance Parameters Summary Table

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Spatial resolution: Distinguishing two points | FWHM (mm) | Smaller = better | Collimator + crystal + PMT
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Sensitivity: Photon detection rate | cps/MBq | Larger = better | Collimator geometry
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Uniformity: Homogeneous response | % variation | Smaller = better | PMT + crystal + electronics
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Energy resolution: Energy discrimination | % FWHM | Smaller = better | Crystal + PMT + statistics
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Count rate performance: Accuracy at high rate | kcps | Larger = better | Electronics + dead time
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Spatial linearity: Straight-line accuracy | mm deviation | Smaller = better | PMT + correction map

Key Points for the Board

SPECT/CT – Additional Points

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First commercial SPECT/CT: GE, 1999 → low-dose single-slice CT (~3.5 mm)
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The effective dose contribution of CT is ~1-10 mSv; low-mAs CT is often sufficient for localisation/AC
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HU = [(µtissue − µwater)/µwater] × 1000; HU → µ conversion is bilinear (with a phantom)
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Misregistration: Respiration (SPECT averaged vs CT instantaneous), table sag, axial centre offset
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Truncation, beam hardening, metal, iodinated contrast → AC artefacts
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Dosimetry: VOIs are drawn on CT → transferred to SPECT; successive time points are aligned by CT–CT non-rigid registration
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Dedicated brain SPECT (ring) ~3 mm; whole-body SPECT ~7-12 mm

Gamma Camera Components – Key Points to Memorise

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Inventor of the gamma camera: Hal Anger (1958)
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Signal flow: Gamma photon → Collimator → Crystal (NaI(Tl)) → Light guide → PMT → Position calculation (X,Y) →

Energy analysis (Z pulse) → Image

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Standard crystal thickness: 3/8 inch (~9.5 mm) → optimised for Tc-99m (140 keV)
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Number of PMTs: Typically 37-91, hexagonal array
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Z pulse = ΣSᵢ → represents the photon energy
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Anger logic: X, Y position calculated by the weighted mean (centroid) method

Collimator Selection – Quick Decision Table

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Tc-99m (140 keV) → LEHR (bone, thyroid) or LEAP (dynamic studies)
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Tl-201 (70-167 keV) → LEHR or LEAP
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Ga-67 (93-300 keV) → ME (Medium Energy)
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In-111 (171-245 keV) → ME (Medium Energy)
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I-131 (364 keV) → HE (High Energy)
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Thyroid (small organ) → Pinhole

Collimator Comparison – Critical Differences

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The only collimator that inverts the image → Pinhole
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Collimators that magnify → Pinhole (at close range) and converging
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Collimator that minifies → Diverging
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Distance↑ → collimator whose sensitivity stays constant → Parallel-hole
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Distance↑ → collimator whose resolution and sensitivity both decrease → Pinhole
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Most widely used collimator → Parallel-hole (LEHR)

Collimator Resolution Formula (Memorise!)

Rc = d × (L + z) / L

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d: hole diameter, L: hole length, z: source-collimator distance
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z↑ → Rc↑ (worsens) | d↑ → Rc↑ (worsens) | L↑ → Rc↓ (improves)
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If the hole diameter is increased 2 times → sensitivity increases ~4 times and resolution worsens ~2 times (sensitivity ∝ Rc²)
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Pinhole/converging magnification (M) reduces the intrinsic resolution contribution to Ri/M → for a close object the system resolution may be better than the intrinsic resolution

Total Resolution Formula (Memorise!)

Rs = √(Rᵢ² + Rc²)

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Rc >> Rᵢ → The collimator is the limiting component

SPECT Acquisition – Critical Parameters

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Cardiac SPECT: 180° acquisition (RAO 45° → LPO 45°), 90° (L-mode) dual-head, 64×64 matrix
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General SPECT (bone, brain): 360° acquisition, 180° configuration dual-head, 128×128 matrix
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Body-contour orbit → distance minimised → resolution optimised
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Step-and-shoot → the most common acquisition mode
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Cardiac SPECT slice planes: SA (short axis), VLA (vertical long axis), HLA (horizontal long axis)

SPECT/CT – Critical Points

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The two basic functions of CT: Anatomical localisation + attenuation correction (CTAC)
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CTAC principle: CT HU values → converted into µ values appropriate to the SPECT photon energy → attenuation map
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Metallic implant → streak artefact on CT → falsely high HU → overcorrection for attenuation → hot artefact (spuriously increased uptake)
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IV contrast → same mechanism → hot artefact → solution: non-contrast CT or acquire CT before contrast
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Misregistration → SPECT-CT mismatch → wrong anatomical localisation + incorrect attenuation correction → cause: patient motion, respiration
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NOT an advantage of SPECT/CT → increased temporal resolution (on the contrary, temporal mismatch is a disadvantage)

Performance Parameters – Critical Points to Memorise

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Component limiting total resolution → Collimator (Rc >> Rᵢ)
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Total resolution formula → Rs = √(Rᵢ² + Rc²)
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Most important daily quality control test → Uniformity
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Measurement of intrinsic uniformity → Collimator REMOVED + point source (at 5 × FOV from the crystal)
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Measurement of system (extrinsic) uniformity → Collimator FITTED + flood source
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Most common cause of non-uniformity → PMT gain drift
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Order of corrections → First energy → then linearity → then uniformity
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Dead-time behaviour of the gamma camera → Paralysable (extendable) → paradoxical fall in counts at very high count rate (paralysis)
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Sensitivity-resolution relationship → Inversely proportional (trade-off) → determined by collimator selection
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LEHR: Best resolution / lowest sensitivity
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LEHS: Best sensitivity / lowest resolution
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LEAP: Intermediate balance

Energy Window – Quick Reference

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Tc-99m: 140 keV ± 10% (20% window)
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I-131: 364 keV ± 10% (20% window)
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Tl-201: 70 keV + 167 keV (dual window)
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Ga-67: 93 + 185 + 300 keV (triple window)
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In-111: 171 + 245 keV (dual window)
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Narrow window → scatter rejection↑ → contrast↑ → sensitivity↓
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Wide window → sensitivity↑ → scatter↑ → contrast↓
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Two radionuclides on the same day: lower energy first, then higher energy (downscatter avoided; e.g. Xe-133 ventilation → Tc-99m MAA perfusion)

Crystal Thickness – Table of Effects

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Thick crystal → Sensitivity↑ + intrinsic resolution↓ → for high-energy radionuclides
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Thin crystal → Sensitivity↓ + intrinsic resolution↑ → for low-energy radionuclides
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Standard 3/8 inch → optimal for Tc-99m (140 keV) → absorbs ~90% of the photons
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The same crystal absorbs only ~30% of the 364 keV photons of I-131 (intrinsic efficiency falls with energy)
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NEMA: CFOV = 75% of the linear dimensions of the UFOV; 9-point filter before calculation
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Signs of crystal damage: Yellow discoloration (yellowing), cold spots, non-uniformity → cannot be repaired, must be replaced Frequently Asked "Which One?" Exam Questions – Quick Answer Cards

1. "The most important component determining the spatial resolution of the gamma camera?" → Collimator 2. "The most important component determining the sensitivity of the gamma camera?" → Collimator 3. "The most important daily quality control test?" → Uniformity 4. "The most common cause of non-uniformity?" → PMT gain drift 5. "The collimator that inverts the image?" → Pinhole 6. "The collimator used in thyroid scintigraphy?" → Pinhole 7. "The collimator whose sensitivity does not change with distance?" → Parallel-hole 8. "The collimator whose resolution and sensitivity both decrease with distance?" → Pinhole 9. "Acquisition angle in cardiac SPECT?" → 180° (RAO 45° → LPO 45°) 10. "Detector configuration in cardiac SPECT?" → 90° (L-mode) 11. "Standard crystal thickness?" → 3/8 inch (~9.5 mm) 12. "What does the Z pulse represent?" → Photon energy 13. "Dead-time type of the gamma camera?" → Paralysable 14. "Order of corrections?" → Energy → Linearity → Uniformity 15. "Metallic implant artefact in SPECT/CT?" → Hot artefact (spuriously increased uptake) 16. "Collimator for Ga-67?" → ME (Medium Energy) 17. "Collimator for I-131?" → HE (High Energy) 18. "If a high-energy radionuclide is imaged with a low-energy collimator?" → Septal penetration → star artefact

19. "Advantage of the converging collimator?" → Higher sensitivity than the parallel-hole collimator 20. "Why is the body-contour orbit preferred?" → Detector-patient distance minimised → resolution optimised

Current guidelines on this chapter's topics

The latest guidelines and consensus documents on the procedures covered in this chapter (official EANM index and primary sources, November 2026). Comparison of the text with these versions is in progress; consult the guideline itself for details.

  1. 2022EANM practice guideline for quantitative SPECT-CT. (opens in a new tab)
  2. 2010Routine Quality Control Recommendations for Nuclear Medicine Instrumentation (opens in a new tab)
  3. 2010Acceptance Testing for Nuclear Medicine Instrumentation (opens in a new tab)

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γ photons interact at different depths in the crystal. A thick crystal catches more photons (sensitivity ↑). But the interaction is on average farther from the PMTs, the light spreads into a wider spot, the PMT signals become more alike and the position is computed less precisely (intrinsic resolution ↓). 3/8 inch is a good balance for 140 keV; at high energy the same crystal misses most photons.

Crystal thickness and light spreadNaI(Tl) · 3/8 inch (9.5 mm) · γ Tc-99m 140 keVIncoming 0 · interacting 0 (0%)Light spot of last event (FWHM): – mmPMTPMTPMT
Fraction of photons absorbed (NaI)0204060801000510152025crystal thickness (mm)photons interacting (%)○ selected: 91.7%Tc-99m 140 keVI-131 364 keV511 keVMean light spot in this crystal (FWHM) ≈ 28 mm

The γ photon is absorbed in the crystal and its light spreads to all PMTs. The PMT nearest the event receives the most light and gives the largest signal. The position (X, Y) is the mean of the PMT positions weighted by their signals. The sum of all signals (Z) gives the energy: if Z is in the window the event is added to the image, and a low-energy photon scattered in the patient is rejected. With 76 mm PMTs the position is found to within a few mm.

Anger logic: position and energyPMT signal (Sᵢ, relative to largest)middle row · vertical not to scaleNaI(Tl)scattered γ
Top view: 37 PMTs and computed positions6 point sources; PMT diameter ~76 mmComputed position within ±2 mm (intrinsic resolution 3–4 mm)

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Role of the collimator

The collimator passes to the crystal only photons travelling along the holes and absorbs the others in the septa, so each point lands in its own place on the crystal and an image forms. The price is sensitivity: only a very small fraction of photons get through. The collimator is the main determinant of both resolution and sensitivity, which are inversely related.

Parallel-holeNo magnification · not inverted · distance↑ → resolution↓, sensitivity constantCrystalObjectImage
Upper half of the object orange, lower half blue. Photon numbers and angles are not to scale: in reality the collimator passes only a very small fraction of photons.

Step 1/3

180° opposed

Two detectors face each other on opposite sides of the patient and rotate in steps; one projection is acquired at each stop. One covers the front half, the other the back half: a 180° rotation collects 360° of data. The same data take twice as long with one head. Used for bone, brain and whole-body SPECT.

Dual head, 180° opposedAntPostRightLeft
Projection angles acquiredAntPostRightLeftDetector 1Detector 2Gantry rotation 0° → angle acquired 0°Projection 0/128 · 0 min (20 s/projection)Same data with one head: ~43 min

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Oblique axis

The left ventricle's long axis runs from base to apex anteriorly, to the left and downward. Transaxial slices taken relative to the body therefore cut the ventricle obliquely: wall thickness and shape change from slice to slice, and segments are hard to compare.

The heart's axis is oblique to the bodyLeftAntHead
Transaxial sliceAntPostRightLeftz = +0.0 cm

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Effect of distance

The object moves away from and towards the collimator. With a parallel-hole collimator the image blurs as distance increases (Rc = d·(L+z)/L grows) but sensitivity is unchanged. With a pinhole, magnification (M = f/z) and sensitivity (~1/z²) decrease with distance. This is why the source is brought as close to the collimator as possible.

Collimator:
Parallel-holeNo magnification · not inverted · distance↑ → resolution↓, sensitivity constantz = 5 cmCrystalObjectImage
Upper half of the object orange, lower half blue. Photon numbers and angles are not to scale: in reality the collimator passes only a very small fraction of photons.
Collimator resolution (Rc)
3.6 mm
System resolution (Rs)
5.1 mm
Sensitivity
Independent of distance

Parallel-hole: typical LEHR collimator (hole diameter d = 1.5 mm, hole length L = 35 mm), Rc = d·(L + z)/L; intrinsic resolution Ri = 3.5 mm (typically 3-4 mm in the book), Rs = √(Ri² + Rc²). Pinhole: M = f/z, example pinhole-crystal distance f = 20 cm (varies by manufacturer); sensitivity ~1/z².